Pericardial effusion due to hypothyroidism in Down syndrome: report of four cases. Dinleyici E, Ucar B, Kilic Z, Dogruel N, Yarar C. Case Reports 2007; 28(2): 141-144 PubMed PMID: 17435671 Keywords: Child, Preschool, Congenital Hypothyroidism:complications, Down Syndrome:complications, Female, Follow-Up Studies, Humans, Infant, Male, Pericardial Effusion:diagnosis, Thyroid Function Tests, Thyroxine:therapeutic use,. Citation : Pericardial effusion may be the first sign of congenital or acquired hypothyroidism and will completely resolve after thyroxin therapy. ..... Read abstract Full text PDF