Induction of cytochromes P450 in small intestine by chemopreventive compounds.
OBJECTIVES: Since flavonoids and other natural compounds exert beneficial effects on human health, their consumption rapidly increases. Ho.....
Krizkova J, Burdova K, Hudecek J, Stiborova M, Hodek P.
Journal Article 2008; 29(5): 717-721 PubMed PMID: 18987596 Keywords: Allyl Compounds:pharmacology, Animals, Anticarcinogenic Agents:pharmacology, Blotting, Western, Curcumin:pharmacology, Cytochrome P-450 CYP1A1:biosynthesis, Cytochrome P-450 CYP2B1:biosynthesis, Cytochrome P-450 Enzyme System:biosynthesis, Flavonoids:phar. CitationOBJECTIVES: Since flavonoids and other natural compounds exert beneficial effects on human health, their consumption rapidly increases. Ho.....
Krizkova J, Burdova K, Hudecek J, Stiborova M, Hodek P. Induction of cytochromes P450 in small intestine by chemopreventive compounds. Neuro Endocrinol Lett. 2008 Oct; 29(5): 717-721
Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, Frei E, Stiborova M.
Journal Article 2008; 29(5): 728-732 PubMed PMID: 18987592 Keywords: Acetyl Coenzyme A:metabolism, Arylamine N-Acetyltransferase:metabolism, Arylsulfotransferase:metabolism, Autoradiography, Catalysis, DNA:chemistry, DNA Adducts:chemistry, Deoxyguanosine:chemistry, Ellipticines:chemistry, Hydrogen-Ion Concentration, Indica. CitationOBJECTIVES: Ellipticine is a potent antineoplastic agent exhibiting multiple mechanisms of its action. Recently, we have found that 13-hyd.....
Moserova M, Kotrbova V, Rupertova M, Naiman K, Hudecek J, Hodek P, Frei E, Stiborova M. Isolation and partial characterization of the adduct formed by 13-hydroxyellipticine with deoxyguanosine in DNA. Neuro Endocrinol Lett. 2008 Oct; 29(5): 728-732
Sulc M, Hudecek J, Stiborova M, Hodek P.
Journal Article 2008; 29(5): 722-727 PubMed PMID: 18987581 Keywords: Adamantane:analogs & derivatives, Amino Acid Sequence, Animals, Arginine:genetics, Aryl Hydrocarbon Hydroxylases:antagonists & inhibitors, Chromatography, High Pressure Liquid, Crystallography, X-Ray, Cytochrome P450 Family 2, Enzyme Inhibitors:pharmacolo. CitationOBJECTIVES: Understanding the enzyme mechanism of P450 enzymes needs a detailed knowledge of substrate-enzyme interactions. Here, we exami.....
Sulc M, Hudecek J, Stiborova M, Hodek P. Structural analysis of binding of a diamantoid substrate to cytochrome P450 2B4: possible role of Arg 133 in modulation of function and activity of this enzyme. Neuro Endocrinol Lett. 2008 Oct; 29(5): 722-727