Vol. 30 (1) 2009 Neuro endocrinology letters

Enhancement of oral bioavailability of insulin in humans.

OBJECTIVE: The purpose of this study is to investigate oral absorption of 1, 2 and 3 U/kg oral insulin five test products with different particle sizes in comparison with 0.1 U/kg subcutaneous reference formulation.

METHODS: Twenty five healthy volunteers participated in five studies using a two-phase, two-sequen.....