Vol. 29 (4) 2008 Neuro endocrinology letters

Up-regulation of gonadotropin alpha-subunit gene by phosphatidylinositol 3-kinase inhibitors in clonal gonadotroph cells.

OBJECTIVE: Phosphatidylinositol-3 kinase (PI3-kinase) has been known to play an important role in cell survival and proliferation by activation of its downstream target, Akt/protein kinase B (PKB). In this present study, we investigated the effects of PI3-kinase inhibitors on gonadotropin alpha-subunit gene expression in pituitary gonad.....